General information
Inflammatory neuropathies are a diverse group of diseases characterized by the presence of an autoimmune attack on the peripheral nerves. Depending on the type of involvement, the way of presentation and the electrophysiological characteristics they are classified into different groups. They all are rare diseases and sometimes difficult to diagnose.
There are acute and chronic inflammatory neuropathies and, although they generally respond to immunomodulatory or immunosuppressive treatments, all of them can determine a significant disability in most patients.
There are acute inflammatory neuropathies such as Guillain-Barré syndrome (all variants) and chronic, such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or multifocal motor neuropathy (MMN). The group of inflammatory neuropathies also includes neuropathies associated with monoclonal gammopathy or vasculitic neuropathies.
These are rare diseases whose knowledge is quite limited. Furthermore, little is known of its pathophysiology, so there are no specific biomarkers and, therefore, these disases can be difficult to diagnose or go unnoticed. In some cases, for example in CIDP, the diagnosis is based solely on clinical and electrophysiological criteria, as there are no specific diagnostic biomarkers .
One of the main research lines of our group is to find biomarkers in inflammatory neuropathies that may aid diagnosis and can guide treatment. In this regard we work in 3 main lines:
- Study antiganglioside antibodies in Guillain-Barré syndrome and clinical variants. In this field we have been able to describe antiganglioside reactivities that identify subtypes of Guillain – Barré syndrome with diagnostic and prognostic specific features.
- Study the presence of autoantibodies in CIDP. In this field our primary goal is to find specific autoantibodies that serve to better diagnose this disease. Our group has reported that the presence of anti-contactin1 or anti-Neurofascin 155 antibodies is related to two specific subtypes of CIDP that do not respond well to conventional therapies. These studies may help to better manage both diagnosis and treatment of patients with CIDP.
- Finally, we are interested in studying the immunopathogenesis of these diseases to try to discover the mechanisms involved in the loss of tolerance against nerve structures and, therefore, related with the onset of the disease.
Publications
2025
Querol L, Dalakas MC
Neurol Neuroimmunol Neuroinflamm
Reyes-Leiva D, Carbayo Á, Vesperinas-Castro A, Rojas-García R, Querol L, Turon-Sans J, Pla-Junca F, Olivé M, Gallardo E, Pujades-Rodriguez M, Cortés-Vicente E
Eur J Neurol
2024
Leonhard SE, Papri N, Querol L, Rinaldi S, Shahrizaila N, Jacobs BC
Nat Rev Dis Primers
Blanco-Ruiz M, Martín-Aguilar L, Caballero-Ávila M, Lleixà C, Pascual-Goñi E, Collet-Vidiella R, Tejada-Illa C, Turon-Sans J, Carbayo Á, Llansó L, Cortés E, Amaya Pascasio L, Querol L
Eur J Neurol
Caballero-Ávila M, Martín-Aguilar L, Pascual-Goñi E, Michael MR, Koel-Simmelink MJA, Höftberger R, Wanschitz J, Alonso-Jiménez A, Armangué T, Baars AE, Carbayo Á, Castek B, Collet-Vidiella R, De Winter J, Del Real MÁ, Delmont E, Diamanti L, Doneddu PE, Hiew FL, Gallardo E, Gonzalez A, Grinzinger S, Horga A, Iglseder S, Jacobs BC, Jauregui A, Killestein J, Pozza EL, Martínez-Martínez L, Nobile-Orazio E, Ortiz N, Pérez-Pérez H, Poppert KN, Ripellino P, Roche JC, Rodriguez de Rivera FJ, Rostasy K, Sparasci D, Tejada-Illa C, Teunissen CCE, Vegezzi E, Xuclà-Ferrarons T, Zach F, Wieske L, Eftimov F, Lleixà C, Querol L
Ann Neurol
Liberatore G, De Lorenzo A, Giannotta C, Manganelli F, Filosto M, Cosentino G, Cocito D, Briani C, Cortese A, Fazio R, Lauria G, Clerici AM, Rosso T, Marfia GA, Antonini G, Cavaletti G, Carpo M, Doneddu PE, Spina E, Cotti Piccinelli S, Peci E, Querol L, Nobile-Orazio E
Neurol Sci
Michael MR, Wieske L, Allen JA, Lunn MP, Doppler K, Tan CY, Koike H, Markvardsen LK, Kapoor M, Hsieh ST, Nobile-Orazio E, Jacobs BC, Rajabally YA, Basta I, Ripellino P, Querol L, Eftimov F, INCbase Consortium
BMC Neurol
Allen JA, Lin J, Basta I, Dysgaard T, Eggers C, Guptill JT, Gwathmey KG, Hewamadduma C, Hofman E, Hussain YM, Kuwabara S, Le Masson G, Leypoldt F, Chang T, Lipowska M, Lowe M, Lauria G, Querol L, Simu MA, Suresh N, Tse A, Ulrichts P, Van Hoorick B, Yamasaki R, Lewis RA, van Doorn PA, ADHERE Study Group
Lancet Neurol
Pascual-Goñi E, Caballero-Ávila M, Querol L
Neurology
Querol L, De Sèze J, Dysgaard T, Levine T, Rao TH, Rivner M, Hartung HP, Kiessling P, Shimizu S, Marmol D, Bozorg A, Colson AO, Massow U, Eftimov F, CIDP01 Study Investigators
J Neurol Neurosurg Psychiatry
Martínez-Martínez L, Lacruz AC, Querol L, Cortés-Vicente E, Pascual E, Rojas-García R, Reyes-Leiva D, Álvaro Y, Moltó E, Ortiz E, Gallardo E, Juárez C, Mariscal A, 2022 GEAI-S. E. I. Workshop participants
J Neurol
Caballero-Ávila M, Lleixà C, Pascual-Goñi E, Martín-Aguilar L, Vidal-Fernandez N, Tejada-Illa C, Collet-Vidiella R, Rojas-Garcia R, Cortés-Vicente E, Turon-Sans J, Gallardo E, Olivé M, Vesperinas A, Carbayo Á, Llansó L, Martinez-Martinez L, Shock A, Christodoulou L, Dizier B, Freeth J, Soden J, Dawson S, Querol L
Neurol Neuroimmunol Neuroinflamm
2023
Broers MC, Wieske L, Erdag E, Gürlek C, Bunschoten C, van Doorn PA, Eftimov F, Kuitwaard K, de Vries JM, de Wit MY, Nagtzaam MM, Franken SC, Zhu L, Paunovic M, de Wit M, Schreurs MW, Lleixà C, Martín-Aguilar L, Pascual-Goñi E, Querol L, Jacobs BC, Huizinga R, Titulaer MJ
J Neurol Neurosurg Psychiatry
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
J Peripher Nerv Syst
Blanco Y, Escudero D, Lleixà C, Llufriu S, Egri N, García RR, Alba M, Aguilar E, Artola M, Aldea Novo M, Alvarez S, Caballero E, Cabrera-Maqueda JM, Fonseca E, Guasp M, Hernando A, Martinez-Hernandez E, Olivé-Cirera G, Lopez-Contreras J, Martín-Aguilar L, Martinez-Martinez L, Rombauts A, Rodés M, Sabater L, Sepulveda M, Solana E, Tejada-Illa C, Vidal-Fernández N, Vilella A, Fortuny C, Armangué T, Dalmau JO, Querol L, Saiz A
Neurol Neuroimmunol Neuroinflamm
Collet R, Caballero-Ávila M, Querol L
Rev Neurol (Paris)
Al-Hakem H, Doets AY, Stino AM, Zivkovic SA, Andersen H, Willison HJ, Cornblath DR, Gorson KC, Islam Z, Mohammad QD, Sindrup SH, Kusunoki S, Davidson A, Casasnovas C, Bateman K, Miller JAL, van den Berg B, Verboon C, Roodbol J, Leonhard SE, Arends S, Luijten LWG, Benedetti L, Kuwabara S, Van den Bergh P, Monges S, Marfia GA, Shahrizaila N, Galassi G, Pereon Y, Bürmann J, Kuitwaard K, Kleyweg RP, Marchesoni C, Sedano Tous MJ, Querol L, Martín-Aguilar L, Wang Y, Nobile-Orazio E, Rinaldi S, Schenone A, Pardo J, Vermeij FH, Waheed W, Lehmann HC, Granit V, Stein B, Cavaletti G, Gutiérrez-Gutiérrez G, Barroso FA, Visser LH, Katzberg HD, Dardiotis E, Attarian S, van der Kooi AJ, Eftimov F, Wirtz PW, Samijn JPA, Gilhuis HJ, Hadden RDM, Holt JKL, Sheikh KA, Kolb N, Karafiath S, Vytopil M, Antonini G, Feasby TE, Faber C, Kramers H, Busby M, Roberts RC, Silvestri NJ, Fazio R, van Dijk GW, Garssen MPJ, Verschuuren J, Harbo T, Jacobs BC, IGOS Consortium
Neurology
Querol L, Lewis RA, Hartung HP, Van Doorn PA, Wallstroem E, Luo X, Alonso-Alonso M, Atassi N, Hughes RAC
J Peripher Nerv Syst
Hamadeh T, van Doormaal PTC, Pruppers MHJ, van de Mortel JPM, Hoeijmakers JGJ, Cornblath DR, Vrancken AFJE, Faber CG, Notermans NC, Merkies ISJ, IMAGiNe Consortium
J Peripher Nerv Syst
Lleixà C, Caballero-Ávila M, Pascual-Goñi E, Martín-Aguilar L, Vidal N, Tejada C, Valdés-Hevia E, Zárate E, Vesperinas A, Collet R, Franco-Leyva T, Martínez-Martínez L, Moga E, Cortés-Vicente E, Rojas-García R, Gómez-Anson B, Gil A, González-Mingot C, Brieva L, Martínez-Yélamos S, Querol L
Brain Commun
Luijten LWG, Doets AY, Arends S, Dimachkie MM, Gorson KC, Islam B, Kolb NA, Kusunoki S, Papri N, Waheed W, Walgaard C, Yamagishi Y, Lingsma H, Jacobs BC, IGOS Consortium
J Neurol Neurosurg Psychiatry
Taieb G, Jentzer A, Vegezzi E, Lleixà C, Illa I, Querol L, Devaux JJ
Front Immunol
2022
Davies AJ, Lleixà C, Siles AM, Gourlay DS, Berridge G, Dejnirattisai W, Ramírez-Santana C, Anaya JM, Falconar AK, Romero-Vivas CM, Osorio L, Parra B, Screaton GR, Mongkolsapaya J, Fischer R, Pardo CA, Halstead SK, Willison HJ, Querol L, Rinaldi S
Neurol Neuroimmunol Neuroinflamm
Leonhard SE, van der Eijk AA, Andersen H, Antonini G, Arends S, Attarian S, Barroso FA, Bateman KJ, Batstra MR, Benedetti L, van den Berg B, Van den Bergh P, Bürmann J, Busby M, Casasnovas C, Cornblath DR, Davidson A, Doets AY, van Doorn PA, Dornonville de la Cour C, Feasby TE, Fehmi J, Garcia-Sobrino T, Goldstein JM, Gorson KC, Granit V, Hadden RDM, Harbo T, Hartung HP, Hasan I, Holbech JV, Holt JKL, Jahan I, Islam Z, Karafiath S, Katzberg HD, Kleyweg RP, Kolb N, Kuitwaard K, Kuwahara M, Kusunoki S, Luijten LWG, Kuwabara S, Lee Pan E, Lehmann HC, Maas M, Martín-Aguilar L, Miller JAL, Mohammad QD, Monges S, Nedkova-Hristova V, Nobile-Orazio E, Pardo J, Pereon Y, Querol L, Reisin R, Van Rijs W, Rinaldi S, Roberts RC, Roodbol J, Shahrizaila N, Sindrup SH, Stein B, Cheng-Yin T, Tankisi H, Tio-Gillen AP, Sedano Tous MJ, Verboon C, Vermeij FH, Visser LH, Huizinga R, Willison HJ, Jacobs BC, IGOS Consortium
Neurology
Jentzer A, Attal A, Roué C, Raymond J, Lleixà C, Illa I, Querol L, Taieb G, Devaux J, anti–neurofascin-155 study group
Neurol Neuroimmunol Neuroinflamm
Arends S, Drenthen J, van den Bergh P, Franssen H, Hadden RDM, Islam B, Kuwabara S, Reisin RC, Shahrizaila N, Amino H, Antonini G, Attarian S, Balducci C, Barroso F, Bertorini T, Binda D, Brannagan TH, Buermann J, Casasnovas C, Cavaletti G, Chao CC, Dimachkie MM, Fulgenzi EA, Galassi G, Gutiérrez Gutiérrez G, Harbo T, Hartung HP, Hsieh ST, Kiers L, Lehmann HC, Manganelli F, Marfia GA, Mataluni G, Pardo J, Péréon Y, Rajabally YA, Santoro L, Sekiguchi Y, Stein B, Stettner M, Uncini A, Verboon C, Verhamme C, Vytopil M, Waheed W, Wang M, Zivkovic S, Jacobs BC, Cornblath DR, IGOS consortium
Clin Neurophysiol
Liberatore G, De Lorenzo A, Giannotta C, Manganelli F, Filosto M, Cosentino G, Cocito D, Briani C, Cortese A, Fazio R, Lauria G, Clerici AM, Rosso T, Marfia GA, Antonini G, Cavaletti G, Carpo M, Doneddu PE, Spina E, Cotti Piccinelli S, Peci E, Querol L, Nobile-Orazio E
Neurol Sci
Lopez-Soley E, Meca-Lallana JE, Llufriu S, Blanco Y, Gómez-Ballesteros R, Maurino J, Pérez-Miralles F, Forero L, Calles C, Martinez-Gines ML, Gonzalez-Suarez I, Boyero S, Romero-Pinel L, Sempere ÁP, Meca-Lallana V, Querol L, Costa-Frossard L, Sepulveda M, Solana E
J Pers Med
Querol LA, Hartung HP, Lewis RA, van Doorn PA, Hammond TR, Atassi N, Alonso-Alonso M, Dalakas MC
Neurotherapeutics
Doets AY, Walgaard C, Lingsma HF, Islam B, Papri N, Yamagishi Y, Kusunoki S, Dimachkie MM, Waheed W, Kolb N, Gorson KC, Jacobs BC, IGOS Consortium
Ann Neurol
Doets AY, Lingsma HF, Walgaard C, Islam B, Papri N, Davidson A, Yamagishi Y, Kusunoki S, Dimachkie MM, Waheed W, Kolb N, Islam Z, Mohammad QD, Harbo T, Sindrup SH, Chavada G, Willison HJ, Casasnovas C, Bateman K, Miller JAL, van den Berg B, Verboon C, Roodbol J, Leonhard SE, Benedetti L, Kuwabara S, Van den Bergh P, Monges S, Marfia GA, Shahrizaila N, Galassi G, Péréon Y, Bürmann J, Kuitwaard K, Kleyweg RP, Marchesoni C, Sedano Tous MJ, Querol L, Illa I, Wang Y, Nobile-Orazio E, Rinaldi S, Schenone A, Pardo J, Vermeij FH, Lehmann HC, Granit V, Cavaletti G, Gutiérrez-Gutiérrez G, Barroso FA, Visser LH, Katzberg HD, Dardiotis E, Attarian S, van der Kooi AJ, Eftimov F, Wirtz PW, Samijn JPA, Gilhuis HJ, Hadden RDM, Holt JKL, Sheikh KA, Karafiath S, Vytopil M, Antonini G, Feasby TE, Faber CG, Gijsbers CJ, Busby M, Roberts RC, Silvestri NJ, Fazio R, van Dijk GW, Garssen MPJ, Straathof CSM, Gorson KC, Jacobs BC, IGOS Consortium
Neurology
2021
Luijten LWG, Leonhard SE, van der Eijk AA, Doets AY, Appeltshauser L, Arends S, Attarian S, Benedetti L, Briani C, Casasnovas C, Castellani F, Dardiotis E, Echaniz-Laguna A, Garssen MPJ, Harbo T, Huizinga R, Humm AM, Jellema K, van der Kooi AJ, Kuitwaard K, Kuntzer T, Kusunoki S, Lascano AM, Martinez-Hernandez E, Rinaldi S, Samijn JPA, Scheidegger O, Tsouni P, Vicino A, Visser LH, Walgaard C, Wang Y, Wirtz PW, Ripellino P, Jacobs BC, IGOS consortium
Brain
Verghese A, Krishnan D, Chia YK, Querol L, Hiew FL
J Cent Nerv Syst Dis
Lleixà C, Martín-Aguilar L, Pascual-Goñi E, Franco T, Caballero M, de Luna N, Gallardo E, Suárez-Calvet X, Martínez-Martínez L, Diaz-Manera J, Rojas-García R, Cortés-Vicente E, Turón J, Casasnovas C, Homedes C, Gutiérrez-Gutiérrez G, Jimeno-Montero MC, Berciano J, Sedano-Tous MJ, García-Sobrino T, Pardo-Fernández J, Márquez-Infante C, Rojas-Marcos I, Jericó-Pascual I, Martínez-Hernández E, Morís de la Tassa G, Domínguez-González C, Juárez C, Illa I, Querol L
J Neuroinflammation
Van den Bergh PYK, van Doorn PA, Hadden RDM, Avau B, Vankrunkelsven P, Allen JA, Attarian S, Blomkwist-Markens PH, Cornblath DR, Eftimov F, Goedee HS, Harbo T, Kuwabara S, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Sommer C, Topaloglu HA
Eur J Neurol
Querol L, Lleixà C
Neurotherapeutics
Querol L
J Neurol Neurosurg Psychiatry
Verboon C, Harbo T, Cornblath DR, Hughes RAC, van Doorn PA, Lunn MP, Gorson KC, Barroso F, Kuwabara S, Galassi G, Lehmann HC, Kusunoki S, Reisin RC, Binda D, Cavaletti G, Jacobs BC, IGOS consortium, GOS consortium
J Neurol Neurosurg Psychiatry
Querol L, Crabtree M, Herepath M, Priedane E, Viejo Viejo I, Agush S, Sommerer P
J Neurol
Van den Bergh PYK, van Doorn PA, Hadden RDM, Avau B, Vankrunkelsven P, Allen JA, Attarian S, Blomkwist-Markens PH, Cornblath DR, Eftimov F, Goedee HS, Harbo T, Kuwabara S, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Sommer C, Topaloglu HA
J Peripher Nerv Syst
Meca-Lallana JE, Maurino J, Pérez-Miralles F, Forero L, Sepúlveda M, Calles C, Martínez-Ginés ML, González-Suárez I, Boyero S, Romero-Pinel L, Sempere ÁP, Meca-Lallana V, Querol L, Costa-Frossard L, Prefasi D, Gómez-Ballesteros R, Ballesteros J
PLoS One
Wieske L, Martín-Aguilar L, Fehmi J, Lleixà C, Koel-Simmelink MJA, Chatterjee M, van Lierop Z, Killestein J, Verhamme C, Querol L, Rinaldi S, Teunissen CE, Eftimov F
Neurol Neuroimmunol Neuroinflamm
Allen JA, Eftimov F, Querol L
Expert Rev Neurother
Ripellino P, Ventura E, Querol L, Gobbi C
J Peripher Nerv Syst
Pascual-Goñi E, Fehmi J, Lleixà C, Martín-Aguilar L, Devaux J, Höftberger R, Delmont E, Doppler K, Sommer C, Radunovic A, Carvajal A, Smyth S, Williams L, Mazanec R, Potočková V, Hinds N, Cassereau J, Viala K, Lefilliatre M, Nicolas G, Foley P, Leypoldt F, Keddie S, Lunn MP, Zimprich F, Nunkoo VS, Löscher WN, Martínez-Martínez L, Díaz-Manera J, Rojas-Garcia R, Illa I, Rinaldi S, Querol L
Brain
Meca-Lallana JE, Prefasi D, Pérez-Miralles F, Forero L, Sepúlveda M, Calles C, Martínez-Ginés ML, González-Suárez I, Boyero S, Romero-Pinel L, Sempere ÁP, Meca-Lallana V, Querol L, Costa-Frossard L, de Castro-Trapiello H, Canal N, Maurino J
Patient Prefer Adherence
Lunn MP, Cornblath DR, Jacobs BC, Querol L, van Doorn PA, Hughes RA, Willison HJ
Brain
Pascual-Goñi E, Martín-Aguilar L, Lleixà C, Martínez-Martínez L, Simón-Talero MJ, Díaz-Manera J, Cortés-Vicente E, Rojas-García R, Moga E, Juárez C, Illa I, Querol L
Sci Rep
2020
Eftimov F, Lucke IM, Querol LA, Rajabally YA, Verhamme C
Brain
Martín-Aguilar L, Camps-Renom P, Lleixà C, Pascual-Goñi E, Díaz-Manera J, Rojas-García R, De Luna N, Gallardo E, Cortés-Vicente E, Muñoz L, Alcolea D, Lleó A, Casasnovas C, Homedes C, Gutiérrez-Gutiérrez G, Jimeno-Montero MC, Berciano J, Sedano-Tous MJ, García-Sobrino T, Pardo-Fernández J, Márquez-Infante C, Rojas-Marcos I, Jericó-Pascual I, Martínez-Hernández E, Morís de la Tassa G, Domínguez-González C, Illa I, Querol L
J Neurol Neurosurg Psychiatry
Querol L, Crabtree M, Herepath M, Priedane E, Viejo-Viejo I, Agush S, Sommerer P
J Neurol
De Simoni D, Ricken G, Winklehner M, Koneczny I, Karenfort M, Hustedt U, Seidel U, Abdel-Mannan O, Munot P, Rinaldi S, Steen C, Freilinger M, Breu M, Seidl R, Reindl M, Wanschitz J, Lleixà C, Bernert G, Wandinger KP, Junker R, Querol L, Leypoldt F, Rostásy K, Höftberger R
Neurol Neuroimmunol Neuroinflamm
Athanasopoulos D, Motte J, Fisse AL, Grueter T, Trampe N, Sturm D, Tegenthoff M, Sgodzai M, Klimas R, Querol L, Gold R, Pitarokoili K
Ann Clin Transl Neurol
Van den Bergh PYK, van Doorn PA, Jacobs BC, Querol L, Bunschoten C, Cornblath DR
J Peripher Nerv Syst
Verboon C, van den Berg B, Cornblath DR, Venema E, Gorson KC, Lunn MP, Lingsma H, Van den Bergh P, Harbo T, Bateman K, Pereon Y, Sindrup SH, Kusunoki S, Miller J, Islam Z, Hartung HP, Chavada G, Jacobs BC, Hughes RAC, van Doorn PA, IGOS Consortium
J Neurol Neurosurg Psychiatry
2019
Martín-Aguilar L, Pascual-Goñi E, Querol L
Med Clin (Barc)
Pascual-Goñi E, Martín-Aguilar L, Querol L
Curr Opin Neurol
Chronic inflammatory demyelinating polyneuropathy associated with contactin-1 antibodies in a child.
Carrera-García L, Natera-de Benito D, Lleixà C, Ortez C, Colomer J, Nascimento A, Saiz A, Dalmau J, Querol L, Armangué T
Neurol Neuroimmunol Neuroinflamm
Verboon C, Doets AY, Galassi G, Davidson A, Waheed W, Péréon Y, Shahrizaila N, Kusunoki S, Lehmann HC, Harbo T, Monges S, Van den Bergh P, Willison HJ, Cornblath DR, Jacobs BC, IGOS Consortium
Neurology
Duchateau L, Martín-Aguilar L, Lleixà C, Cortese A, Dols-Icardo O, Cervera-Carles L, Pascual-Goñi E, Diaz-Manera J, Callegari I, Franciotta D, Rojas-Garcia R, Illa I, Clarimon J, Querol L
PLoS One
Pascual-Goñi E, Martín-Aguilar L, Lleixà C, Martínez-Martínez L, Simón-Talero MJ, Díaz-Manera J, Cortés-Vicente E, Rojas-García R, Moga E, Juárez C, Illa I, Querol L
Sci Rep
Manso C, Querol L, Lleixà C, Poncelet M, Mekaouche M, Vallat JM, Illa I, Devaux JJ
J Clin Invest
Duchateau L, Martín-Aguilar L, Lleixà C, Cortese A, Dols-Icardo O, Cervera-Carles L, Pascual-Goñi E, Diaz-Manera J, Calegari I, Franciotta D, Rojas-Garcia R, Illa I, Clarimon J, Querol L
PLoS One
2018
Doets AY, Verboon C, van den Berg B, Harbo T, Cornblath DR, Willison HJ, Islam Z, Attarian S, Barroso FA, Bateman K, Benedetti L, van den Bergh P, Casasnovas C, Cavaletti G, Chavada G, Claeys KG, Dardiotis E, Davidson A, van Doorn PA, Feasby TE, Galassi G, Gorson KC, Hartung HP, Hsieh ST, Hughes RAC, Illa I, Islam B, Kusunoki S, Kuwabara S, Lehmann HC, Miller JAL, Mohammad QD, Monges S, Nobile Orazio E, Pardo J, Pereon Y, Rinaldi S, Querol L, Reddel SW, Reisin RC, Shahrizaila N, Sindrup SH, Waqar W, Jacobs BC, IGOS Consortium
Brain
Alessandro L, Pastor Rueda JM, Wilken M, Querol L, Marrodán M, Acosta JN, Rivero A, Barroso F, Farez MF
J Peripher Nerv Syst
Hughes R, Dalakas MC, Merkies I, Latov N, Léger JM, Nobile-Orazio E, Sobue G, Genge A, Cornblath D, Merschhemke M, Ervin CM, Agoropoulou C, Hartung HP, FORCIDP Trial Investigators
Lancet Neurol
Allen JA, Berger M, Querol L, Kuitwaard K, Hadden RD
J Peripher Nerv Syst
Siles AM, Martínez-Hernández E, Araque J, Diaz-Manera J, Rojas-Garcia R, Gallardo E, Illa I, Graus F, Querol L
Ann Clin Transl Neurol
Painous C, López-Pérez MÁ, Illa I, Querol L
Ann Clin Transl Neurol
Draak THP, Faber CG, Merkies ISJ, PeriNomS study Group
J Neurol Neurosurg Psychiatry
Eftimov F, Bunschoten C, Rajabally Y, Querol L, participants of the 231st ENMC workshop
Neuromuscul Disord
2017
Martinez-Martinez L, Lleixà MC, Boera-Carnicero G, Cortese A, Devaux J, Siles A, Rajabally Y, Martinez-Piñeiro A, Carvajal A, Pardo J, Delmont E, Attarian S, Diaz-Manera J, Callegari I, Marchioni E, Franciotta D, Benedetti L, Lauria G, de la Calle Martin O, Juárez C, Illa I, Querol L
J Neuroinflammation
Pruppers MHJ, Merkies ISJ, Lunn MPT, Notermans NC, IMAGiNe Study Group
Neuromuscul Disord
Querol L, Siles AM, Alba-Rovira R, Jáuregui A, Devaux J, Faivre-Sarrailh C, Araque J, Rojas-Garcia R, Diaz-Manera J, Cortés-Vicente E, Nogales-Gadea G, Navas-Madroñal M, Gallardo E, Illa I
Sci Rep
Querol L, Devaux J, Rojas-Garcia R, Illa I
Nat Rev Neurol
Delmont E, Manso C, Querol L, Cortese A, Berardinelli A, Lozza A, Belghazi M, Malissart P, Labauge P, Taieb G, Yuki N, Illa I, Attarian S, Devaux JJ
Brain
Jacobs BC, van den Berg B, Verboon C, Chavada G, Cornblath DR, Gorson KC, Harbo T, Hartung HP, Hughes RAC, Kusunoki S, van Doorn PA, Willison HJ, IGOS Consortium
J Peripher Nerv Syst
Navas-Madroñal M, Valero-Mut A, Martínez-Zapata MJ, Simón-Talero MJ, Figueroa S, Vidal-Fernández N, López-Góngora M, Escartín A, Querol L
PLoS One
2016
Draak TH, Gorson KC, Vanhoutte EK, van Nes SI, van Doorn PA, Cornblath DR, van den Berg LH, Faber CG, Merkies IS, PeriNomS Study Group
Eur J Neurol
Manso C, Querol L, Mekaouche M, Illa I, Devaux JJ
Brain
Draak TH, Gorson KC, Vanhoutte EK, van Nes SI, van Doorn PA, Cornblath DR, van den Berg LH, Faber CG, Merkies IS, PeriNomS Study Group
J Peripher Nerv Syst
2015
Querol L, Rojas-García R, Diaz-Manera J, Barcena J, Pardo J, Ortega-Moreno A, Sedano MJ, Seró-Ballesteros L, Carvajal A, Ortiz N, Gallardo E, Illa I
Neurol Neuroimmunol Neuroinflamm
Querol L, Illa I
Curr Opin Neurol
Vanhoutte EK, Faber CG, van Nes SI, Cats EA, Van der Pol WL, Gorson KC, van Doorn PA, Cornblath DR, van den Berg LH, Merkies IS, PeriNomS Study Group
J Peripher Nerv Syst
Draak TH, Pruppers MH, van Nes SI, Vanhoutte EK, Bakkers M, Gorson KC, Van der Pol WL, Lewis RA, Notermans NC, Nobile-Orazio E, Léger JM, Van den Bergh PY, Lauria G, Bril V, Katzberg H, Lunn MP, Pouget J, van der Kooi AJ, van den Berg LH, van Doorn PA, Cornblath DR, Hahn AF, Faber CG, Merkies IS, PeriNomS study group
J Peripher Nerv Syst
Pruppers MH, Draak TH, Vanhoutte EK, Van der Pol WL, Gorson KC, Léger JM, Nobile-Orazio E, Lewis RA, van den Berg LH, Faber CG, Merkies IS, PeriNomS study group
J Peripher Nerv Syst
Vanhoutte EK, Draak TH, Gorson KC, van Nes SI, Hoeijmakers JG, Van der Pol WL, Notermans NC, Lewis RA, Nobile-Orazio E, Léger JM, Van den Bergh PY, Lauria G, Bril V, Katzberg H, Lunn MP, Pouget J, van der Kooi AJ, Hahn AF, van Doorn PA, Cornblath DR, van den Berg LH, Faber CG, Merkies IS, PeriNomS Study Group
J Peripher Nerv Syst
Draak TH, Vanhoutte EK, van Nes SI, Gorson KC, Van der Pol WL, Notermans NC, Nobile-Orazio E, Lewis RA, Léger JM, Van den Bergh PY, Lauria G, Bril V, Katzberg H, Lunn MP, Pouget J, van der Kooi AJ, Hahn AF, van den Berg LH, van Doorn PA, Cornblath DR, Faber CG, Merkies IS, PeriNomS Study Group
J Peripher Nerv Syst
Huijbers MG, Querol LA, Niks EH, Plomp JJ, van der Maarel SM, Graus F, Dalmau J, Illa I, Verschuuren JJ
Eur J Neurol
2014
Labasque M, Hivert B, Nogales-Gadea G, Querol L, Illa I, Faivre-Sarrailh C
J Biol Chem
Querol L, Nogales-Gadea G, Rojas-Garcia R, Diaz-Manera J, Pardo J, Ortega-Moreno A, Sedano MJ, Gallardo E, Berciano J, Blesa R, Dalmau J, Illa I
Neurology
2013
Querol L, Rojas-Garcia R, Casasnovas C, Sedano MJ, Muñoz-Blanco JL, Alberti MA, Paradas C, Sevilla T, Pardo J, Capablo JL, Sivera R, Guerrero A, Gutierrez-Rivas E, Illa I
Muscle Nerve
Vanhoutte EK, Faber CG, Merkies IS, PeriNomS study group
Neuromuscul Disord
Querol L, Nogales-Gadea G, Rojas-Garcia R, Martinez-Hernandez E, Diaz-Manera J, Suárez-Calvet X, Navas M, Araque J, Gallardo E, Illa I
Ann Neurol
2012
Rojas-García R, Querol L, Gallardo E, De Luna Salva N, Juarez C, Garces M, Fages E, Casasnovas C, Illa I
J Peripher Nerv Syst
Vanhoutte EK, Faber CG, van Nes SI, Jacobs BC, van Doorn PA, van Koningsveld R, Cornblath DR, van der Kooi AJ, Cats EA, van den Berg LH, Notermans NC, van der Pol WL, Hermans MC, van der Beek NA, Gorson KC, Eurelings M, Engelsman J, Boot H, Meijer RJ, Lauria G, Tennant A, Merkies IS, PeriNomS Study Group
Brain
2010
Joint Task Force of the EFNS and the PNS
J Peripher Nerv Syst
Joint Task Force of the EFNS and the PNS
J Peripher Nerv Syst
Van den Bergh PY, Hadden RD, Bouche P, Cornblath DR, Hahn A, Illa I, Koski CL, Léger JM, Nobile-Orazio E, Pollard J, Sommer C, van Doorn PA, van Schaik IN, European Federation of Neurological Societies, Peripheral Nerve Society
Eur J Neurol
Joint Task Force of the EFNS and the PNS
J Peripher Nerv Syst
2009
Berciano J, García A, Villagrá NT, González F, Ramón C, Illa I, Berciano MT, Lafarga M
J Peripher Nerv Syst
Díaz-Manera J, Rojas-García R, Gallardo E, Illa I
Muscle Nerve
2006
European Federation of Neurological Societies, Peripheral Nerve Society, Hadden RD, Nobile-Orazio E, Sommer C, Hahn A, Illa I, Morra E, Pollard J, Hughes RA, Bouche P, Cornblath D, Evers E, Koski CL, Léger JM, Van den Bergh P, van Doorn P, van Schaik IN
Eur J Neurol
European Federation of Neurological Societies, Peripheral Nerve Society, van Schaik IN, Bouche P, Illa I, Léger JM, Van den Bergh P, Cornblath DR, Evers EM, Hadden RD, Hughes RA, Koski CL, Nobile-Orazio E, Pollard J, Sommer C, van Doorn PA
Eur J Neurol
Hughes RA, Bouche P, Cornblath DR, Evers E, Hadden RD, Hahn A, Illa I, Koski CL, Léger JM, Nobile-Orazio E, Pollard J, Sommer C, Van den Bergh P, van Doorn PA, van Schaik IN
Eur J Neurol
2005
Berciano J, Illa I
Neurology
2003
McCrone P, Chisholm D, Knapp M, Hughes R, Comi G, Dalakas MC, Illa I, Kilindireas C, Nobile-Orazio E, Swan A, Van den Bergh P, Willison HJ, INCAT Study Group
Eur J Neurol
Dourado ME, Duarte RC, Ferreira LC, Queiroz JW, Illa I, Perez-Perez G, Guerrant RL, Jerônimo SM
Acta Neurol Scand
2002
Rojas-García R, Tizzano E, Cuscó I, Gallardo E, Barceló MJ, de Andrés I, Larrodé P, Martí-Massó JF, Martínez-Matos JA, Povedano M, Rallo B, Serrano S, Baiget M, Illa I
Neurology
2001
Hughes R, Bensa S, Willison H, Van den Bergh P, Comi G, Illa I, Nobile-Orazio E, van Doorn P, Dalakas M, Bojar M, Swan A, Inflammatory Neuropathy Cause and Treatment (INCAT) Group
Ann Neurol
Gallardo E, Rojas-García R, Belvís R, Serrano-Munuera C, Ortiz E, Ortiz N, Grau J, Illa I
Neurologia
Rojas-García R, Gallardo E, Serrano-Munuera C, de Luna N, Ortiz E, Roig C, Grau-Veciana JM, Illa I
Med Clin (Barc)
2000
O'Hanlon GM, Veitch J, Gallardo E, Illa I, Chancellor AM, Willison HJ
Autoimmunity
1997
Berciano J, Figols J, García A, Calle E, Illa I, Lafarga M, Berciano MT
Muscle Nerve
1996
Gallardo E, Serrano C, Prat C, Illa I
Neurologia
Basta M, Illa I, Dalakas MC
J Neuroimmunol
1995
Illa I, Ortiz N, Gallard E, Juarez C, Grau JM, Dalakas MC
Ann Neurol
Díez-Tejedor E, Fernández JM, Gutiérrez E, Horga J, Illa I, Matías-Guiu J, Montalbán X, Vioqué J, Alvarez Sabín J
Rev Neurol
Ongoing Projects
International GBS Outcome Study (IGOS)
Estado: Activo
Duración: -2013
Investigador Principal: Marc C. Jacobs, Isabel Illa Sendra (Multicéntrico)
Agencia Financiadora: INC/PNS
Identification of autoantibodies in inflammatory neuropathies and characterization of the cellular phenotype involved in its development
Estado: Activo
Duración: 2017-2020
Investigador Principal: Luis Querol Gutiérrez (Hospital de Sant Pau)
Agencia Financiadora: Instituto de Salud Carlos III, Fondo de Investigacion Sanitaria
Immunological studies relevant to the development of therapeutic strategies in neuromuscular diseases
Estado: Finalizado
Duración: 2010-2014
Investigador Principal: Isabel Illa Sendra (Hospital de Sant Pau)
Agencia Financiadora: Instituto de Salud Carlos III, Fondo de Investigacion Sanitaria
New antigenic reactivities and studies of innate immunity in autoinmune neuromuscular diseases (INMUN-NMD)
Estado: Finalizado
Duración: (2013-2015)
Investigador Principal: Isabel Illa Sendra (Hospital de Sant Pau)
Agencia Financiadora: Instituto de salud Carlos III
ACAMIN. Autoantibodies to cell adhesion molecules in inflammatory neuropathies
Estado: Finalizado
Duración: 2014-2016
Investigador Principal: Isabel Illa Sendra (nacional)
Agencia Financiadora: E- Rare. European research area
Paranodal autoimmunity in CIDP: diagnostic and Therapeutic value Rationale and Objective
Estado: Finalizado
Duración: (2014-2016)
Investigador Principal: Isabel Illa Sendra (Hospital de Sant Pau)
Agencia Financiadora: GBS/ CIDP USA foundation
Autoantibodies to cell adhesion molecules in inflammatory neuropathies ACAMIN
Estado: Finalizado
Duración: (2014-2016)
Investigador Principal: Jérôme Devaux, Isabel Illa Sendra, Elior Peles (Multicéntrico)
Agencia Financiadora: AFM- TÉLÉTHON
Paranodal autoimmunity in CIDP: diagnostic and Therapeutic value
Estado: Finalizado
Duración: 2014-2016
Investigador Principal: Isabel Illa Sendra (nacional)
Agencia Financiadora: GBS/ CIDP USA foundation
IVIg effects on regulatory B cells in patients with neuroimmune diseases
Estado: Finalizado
Duración: 2016
Investigador Principal: Luis Querol Gutiérrez (Hospital de Sant Pau)
Agencia Financiadora: Fundación Grifols
Clínical Trials
CFTY720I2201: A double-blind, randomized, multicenter, placebocontrolled,parallel-group study to evaluate the efficacy and safety of fingolimod 0.5 mg administered orally once daily versus placebo in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
Estado: Finalizado
Ensayo Clínico
I10E-0901 LIME STUDY: European randomized, double-blind, controlled comparator, cross-over design that assesses the safety and efficacy of a new 10% human intravenous immunoglobulin ready-to-use formulation (I10E) compared to Kiovig in patients with multifocal motor neuropathy
Estado: Finalizado
Ensayo Clínico
I10E-1302 PRISM: International multicenter study on the efficacy and safety of I10E in initial treatment and maintenance of patients with chronic inflammatory demyelinating polyradiculoneuropathy
Estado: Finalizado
Ensayo Clínico